KRAS 8 Liphetoho

Liphetoho tse ka sehloohong tsa lefutso la KRAS li fumanoe mefuteng e mengata ea lihlahala tsa batho, hoo e ka bang 17% ~ 25% sekhahla sa phetoho ho hlahala, 15% ~ 30% sekhahla sa phetoho ho bakuli ba mofetše oa matšoafo, 20% ~ 50% sekhahla sa phetoho ho bakuli ba mofetše oa colorectal. Hobane protheine ea P21 e kenngoeng ke mofuta oa K-ras e fumaneha ka tlaase ho tsela ea EGFR ea pontšo, ka mor'a phetoho ea liphatsa tsa lefutso tsa K-ras, tsela ea pontšo e tlaase e lula e sebetsa 'me ha e amehe ke lithethefatsi tse lebisitsoeng holimo ho EGFR, e leng se bakang ho ata ho tsoelang pele ho kotsi ha lisele. Liphetoho tsa mofuta oa K-ras hangata li fana ka khanyetso ho EGFR tyrosine kinase inhibitors ho bakuli ba mofetše oa matšoafo le ho hanyetsa litlhare tsa anti-EGFR ho bakuli ba mofetše oa colorectal. Ka 2008, National Comprehensive Cancer Network (NCCN) e ile ea fana ka tataiso ea kliniki bakeng sa mofetše oa colorectal, e bonts'itseng hore libaka tsa phetoho tse etsang hore K-ras li sebelisoe li fumaneha haholo ho codons 12 le 13 ea exon 2, mme e khothalelitse hore bakuli bohle ba nang le mofetše o tsoetseng pele oa metastatic colorectal pele ba ka hlahlojoa phetoho ea K-ras. Ka hona, ho lemoha ka potlako le ka nepo phetoho ea liphatsa tsa lefutso tsa K-ras ho bohlokoa haholo tataisong ea meriana ea bongaka. Setsi sena se sebelisa DNA e le sampole ea ho lemoha ho fana ka tlhahlobo ea boleng ba boemo ba phetoho, e ka thusang baoki ho hlahloba mofetše oa mala, mofetše oa matšoafo le bakuli ba bang ba hlahala ba ruang molemo ho litlhare tse lebisitsoeng. Liphetho tsa liteko tsa kit ke tsa litšupiso tsa bongaka feela 'me ha lia lokela ho sebelisoa e le eona feela motheo oa kalafo e ikhethileng ea bakuli. Baoki ba lokela ho etsa likahlolo tse felletseng mabapi le liphetho tsa liteko tse ipapisitseng le lintlha tse kang boemo ba mokuli, matšoao a lithethefatsi, karabelo ea kalafo le matšoao a mang a tlhahlobo ea laboratori.