Motho ROS1 Fusion Gene Phetoho

ROS1 ke transmembrane tyrosine kinase ea lelapa la insulin receptor.Mofuta oa fusion oa ROS1 o netefalitsoe e le mofuta o mong oa bohlokoa oa mokhanni oa mofetše oa mofetše oa lisele tse nyane.Joalo ka moemeli oa mofuta o mocha o ikhethang oa limolek'hule, ketsahalo ea ROS1 fusion gene ho NSCLC Hoo e ka bang 1% ho isa ho 2% ROS1 haholo-holo e hlophisoa bocha ka li-exons tsa eona tsa 32, 34, 35 le 36. Ka mor'a hore e kopane le liphatsa tsa lefutso tse kang CD74, EZR, SLC34A2, le SDC4, e tla tsoelapele ho kenya tšebetsong sebaka sa ROS1 tyrosine kinase.ROS1 kinase e sa sebetseng ka mokhoa o sa tloaelehang e ka kenya tšebetsong litsela tse tlase tsa mats'oao tse kang RAS/MAPK/ERK, PI3K/Akt/mTOR, le JAK3/STAT3, ka hona e kenya letsoho keketsehong, karohanong le ho metastasis ea lisele tsa hlahala, le ho baka mofetše.Har'a liphetoho tsa ROS1 fusion, CD74-ROS1 e etsa karolo ea 42%, EZR e etsa karolo ea 15%, SLC34A2 e etsa karolo ea 12%, 'me SDC4 e etsa karolo ea 7%.Liphuputso li bontšitse hore sebaka sa ATP se tlamang sa catalytic domain ea ROS1 kinase le sebaka se tlamang sa ATP sa ALK kinase se na le homology ho fihla ho 77%, kahoo ALK tyrosine kinase e nyenyane ea molek'hule inhibitor crizotinib joalo-joalo e na le phello e hlakileng ea phekolo. kalafong ea NSCLC ka phetoho ea fusion ea ROS1.Ka hona, ho lemoha liphetoho tsa fusion ea ROS1 ke motheo le motheo oa ho tataisa tšebeliso ea lithethefatsi tsa crizotinib.