Meriana ea Tšireletso ea Aspirin

Aspirin, e le sethethefatsi se sebetsang sa anti-platelet aggregation, se sebelisoa haholo ho thibela le ho phekola mafu a pelo le a cerebrovascular.Phuputso e fumana hore bakuli ba bang ba fumanoe ba sitoa ho thibela ka katleho mosebetsi oa liplatelete ho sa tsotellehe tšebeliso ea nako e telele e tlaase ea aspirin, ke hore, aspirin resistance (AR). Sekhahla se ka bang 50% -60%, 'me ho na le phapang e totobetseng ea merabe. Glycoprotein IIb / IIIa (GPI IIb / IIIa) e phetha karolo ea bohlokoa ho bokellaneng ha platelet le thrombosis e matla libakeng tsa kotsi ea methapo. Liphuputso li bontšitse hore liphatsa tsa lefutso tsa polymorphisms li phetha karolo ea bohlokoa tabeng ea ho hanyetsa aspirin, haholo-holo li shebane le GPIIIa P1A1/A2, PEAR1 le PTGS1 gene polymorphisms. GPIIa P1A2 ke mofuta oa mantlha oa ho hanyetsa aspirin. Liphetoho tsa lefutso lena li fetola sebopeho sa li-receptor tsa GPIIb/IIIa, e leng se bakang khokahano lipakeng tsa li-platelet le platelet aggregation. Boithuto bo fumane hore khafetsa ea li-alleles tsa P1A2 ho bakuli ba hananang le aspirin e ne e phahame haholo ho feta ea bakuli ba sa utloeng bohloko ka aspirin, mme bakuli ba nang le liphetoho tsa homozygous tsa P1A2 / A2 ba ne ba sa sebetse hantle kamora ho noa aspirin. Bakuli ba nang le li-alleles tsa P1A2 tse feto-fetohang ba nang le stenting ba na le sekhahla sa ketsahalo ea subacute thrombotic e makhetlo a mahlano ea bakuli ba mofuta oa hlaha oa P1A1 homozygous, e hlokang litekanyetso tse phahameng tsa aspirin ho finyella liphello tsa anticoagulant. PEAR1 GG allele e arabela hantle ho aspirin, 'me bakuli ba nang le AA kapa AG genotype ba noang aspirin (kapa ba kopantsoe le clopidogrel) ka mor'a ho kenngoa ha stent ba na le infarction e phahameng ea myocardial le lefu. PTGS1 GG genotype e na le kotsi e kholo ea ho hanyetsa aspirin (HR: 10) le liketsahalo tse phahameng tsa liketsahalo tsa pelo (HR: 2.55). The AG genotype e na le kotsi e itekanetseng, 'me tlhokomelo e haufi e lokela ho lefshoa phello ea phekolo ea aspirin. AA genotype e na le kutloelo-bohloko ho aspirin, 'me liketsahalo tsa liketsahalo tsa pelo le methapo li batla li le tlaase. Liphetho tsa tlhahlobo ea sehlahisoa sena li emela feela liphetho tsa PEAR1, PTGS1, le liphatsa tsa lefutso tsa GPIIIa.