Meriana ea Tšireletso ea Aspirin

Aspirin, e le moriana o sebetsang oa ho thibela ho bokellana ha liplatelete, e sebelisoa haholo ho thibeleng le kalafong ea mafu a pelo le methapo ea mali. Phuputso e fumane hore bakuli ba bang ba fumanoe ba sa khone ho thibela ts'ebetso ea liplatelete ka katleho ho sa tsotelehe tšebeliso ea aspirin ea nako e telele e tlase, ke hore, ho hanyetsa aspirin (AR). Sekhahla ke hoo e ka bang 50%-60%, 'me ho na le liphapang tse totobetseng tsa merabe. Glycoprotein IIb/IIIa (GPI IIb/IIIa) e bapala karolo ea bohlokoa ho kopaneng ha liplatelete le ho thothomela ha methapo ea mali libakeng tsa kotsi ea methapo ea mali. Lithuto li bontšitse hore li-polymorphism tsa liphatsa tsa lefutso li bapala karolo ea bohlokoa ho hanyetsaneng ha aspirin, haholo-holo li shebane le li-polymorphism tsa liphatsa tsa lefutso tsa GPIIIa P1A1/A2, PEAR1 le PTGS1. GPIIIa P1A2 ke gene e ka sehloohong ea ho hanyetsa aspirin. Liphetoho tsa lefutso lena li fetola sebopeho sa li-receptor tsa GPIIb/IIIa, e leng se fellang ka khokahano lipakeng tsa liplatelete le ho kopana ha liplatelete. Phuputso e fumane hore makhetlo a li-allele tsa P1A2 ho bakuli ba hananang le aspirin a ne a le holimo haholo ho feta a bakuli ba nang le aspirin, 'me bakuli ba nang le liphetoho tsa P1A2/A2 homozygous ba ne ba se na katleho e ntle ka mor'a ho nka aspirin. Bakuli ba nang le li-allele tsa P1A2 tse fetotsoeng tse ntseng li etsoa stenting ba na le sekhahla sa liketsahalo tsa subacute thrombotic se fetang makhetlo a mahlano sa bakuli ba mofuta oa P1A1 homozygous wild, se hlokang litekanyo tse phahameng tsa aspirin ho fihlela litlamorao tsa anticoagulant. Allele ea PEAR1 GG e arabela hantle ho aspirin, 'me bakuli ba nang le genotype ea AA kapa AG ba nkang aspirin (kapa e kopantsoeng le clopidogrel) kamora ho kenngoa ha stent ba na le infarction e phahameng ea myocardial le lefu. Genotype ea PTGS1 GG e na le kotsi e kholo ea ho hanyetsa aspirin (HR: 10) le palo e phahameng ea liketsahalo tsa pelo le methapo ea mali (HR: 2.55). Genotype ea AG e na le kotsi e itekanetseng, 'me tlhokomelo e haufi e lokela ho lefshoa phellong ea kalafo ea aspirin. Genotype ea AA e na le kutloelo-bohloko haholoanyane ho aspirin, 'me palo ea liketsahalo tsa pelo le methapo ea mali e tlase haholo. Liphetho tsa ho lemoha tsa sehlahisoa sena li emela feela liphetho tsa ho lemoha tsa liphatsa tsa lefutso tsa PEAR1, PTGS1, le GPIIIa tsa batho.