Ho Fetola C. Diff Detection: Ho Finyella Tlhahlobo ea Limolek'hule e Iketsang ka Botlalo, e Sampole-ho-Arabang

Ke eng e bakang tšoaetso ea C. Diff?

1. Tšoaetso ea diff e bakoa ke baktheria e tsejoang e le Clostridioides difficile (C. difficile), eo hangata e lulang ka maleng ntle le kotsi. Leha ho le joalo, ha ho hloleha ho leka-lekana ha baktheria ea mala, hangata ho sebelisoa lithibela-mafu tse pharaletseng,C. thatae ka hola haholo mme ya hlahisa chefo, e leng se lebisang tshwaetsong.

Baktheria ena e teng ka mefuta e 'meli ea toxigen le e seng toxigen, empa ke mefuta ea toxigen feela (chefo ea A le B) e bakang mafu. E baka ho ruruha ka ho sitisa lisele tsa epithelial tsa mala. Chefo ea A ke enterotoxin e senyang lera la mala, e eketsa ho kenella ha metsi, le ho hohela lisele tsa 'mele tse lokollang li-cytokine tse ruruhang. Chefo ea B, cytotoxin e matla haholoanyane, e shebana le cytoskeleton ea actin ea lisele, e leng se lebisang ho pota-poteng ha lisele, ho arohana ha tsona, 'me qetellong lefu la lisele. Hammoho, chefo ena e baka tšenyo ea lisele le karabelo e matla ea 'mele ea ho itšireletsa mafung, e iponahatsang e le colitis, letšollo, 'me maemong a boima, pseudomembranous colitis - ho ruruha ho tebileng ha mala a maholo.

C. Diff e ata joang?

1. Bothata bona bo ata habonolo. Bo fumaneha lipetleleng, hangata bo fumanoa li-ICU, matsohong a basebetsi ba sepetlele, fatše le li-handrails tsa sepetlele, li-thermometer tsa elektroniki, le lisebelisoa tse ling tsa bongaka…

Mabaka a Kotsi bakeng sa Tšoaetso ea C. Diff

• Ho kena sepetlele nako e telele;
• Kalafo ea likokoana-hloko;
• Lithethefatsi tsa chemotherapy;
• Opereishene ea morao tjena (matsoho a mpa,ho kheloha ha mpa, opereishene ea mala a maholo);
• Phepo e nepahetseng ea mpa le mala;
• Tšoaetso ea pele ea C. diff;

Matšoao a tšoaetso ea C. Diff

Tšoaetso ea C. diff e ka ba e sa phutholohang haholo. Batho ba bangata ba na le letšollo le sa phutholohang ka mpeng. Matšoao a tloaelehileng haholo ke:letšollo, bohloko ba mpa, ho nyekeloa ke pelo, ho hloka takatso ea lijo, feberu.

Ha tšoaetso ea C. diff e ntse e mpefala le ho feta, ho tla ba le nts'etsopele ea mofuta o rarahaneng haholoanyane oa C. diff o tsejoang e lecolitis, pseudomembranous enteritis esita le lefu.

Tlhahlobo ea Tšoaetso ea C. Diff

Setso sa Baktheria: E na le kutloelo-bohloko empaho nka nako (matsatsi a 2-5), ha e khone ho khethollamefuta ea chefo le e seng chefo;

Setso sa Chefo:e khetholla mefuta e chefo e bakang mafu empa e nka nako e telele (matsatsi a 3-5) mme e sa amehe haholo;

Ho lemoha GDH:e potlakile (lihora tse 1-2) ebile e theko e tlase, e na le kutlo e matla haholo empa e ke ke ea khetholla mefuta ea chefo le e seng chefo;

Teko ea ho se be le chefo ea sele (CCNA):e lemoha chefo A le B ka kutlo e phahameng empa e nka nako (matsatsi a 2-3), mme e hloka libaka tse khethehileng le basebetsi ba koetlisitsoeng;

Chefo A/B ELISA: Teko e bonolo le e potlakileng (lihora tse 1-2) ka kutlo e tlase le liphoso tse fosahetseng tse etsahalang khafetsa;

Liteko tsa ho Eketsa Asiti ea Nyutlelie (li-NAAT): E potlakile (lihora tse 1-3) 'me e na le kutloelo-bohloko haholo le e tobileng, e lemoha liphatsa tsa lefutso tse ikarabellang bakeng sa tlhahiso ea chefo;

Ho phaella moo, liteko tsa ho etsa litšoantšo ho hlahloba mala, joalo kaLiskena tsa CTleMahlaseli a X, e ka boela ea sebelisoa ho thusa ho fumana C. diff le mathata a C. diff, joalo ka colitis.

Kalafo ea tšoaetso ea C. Diff

Ho na le mekhoa e mengata ea kalafo bakeng sa tšoaetso ea C. diff. Ka tlase ke mekhoa e metle ka ho fetisisa:

• Lithibela-mafu tse nooang tse kang vancomycin, metronidazole kapa fidaxomicin li sebelisoa hangata kaha meriana e ka feta tsamaisong ea tšilo ea lijo 'me ea fihla ka mpeng moo libaktheria tsa C. diff li lulang teng.
• Metronidazole e kenngoang ka har'a vein e ka sebelisoa bakeng sa kalafo haeba tšoaetso ea C. diff e le mpe haholo.
• Ho fetisetsa di-microbiota tsa mantle ho bontshitse katleho ho phekoleng ditshwaetso tse atileng tsa C. diff le ditshwaetso tse matla tsa C. diff tse sa arabeleng dithibela-mafu.
• Ho ka hlokahala opereishene bakeng sa maemo a boima.

E nchafatsang dtharollo ea ho lemoha lintho tse sa tloaelehang ho tsoa ho MMT

Ho arabela tlhoko ea ho lemoha C. difficile ka potlako le ka nepo, re hlahisa Kit ea rona e ncha ea ho lemoha Nucleic Acid bakeng sa chefo ea Clostridium difficile gene ea A/B, re matlafatsa litsebi tsa tlhokomelo ea bophelo ho etsa tlhahlobo ea pele le e nepahetseng le ho tšehetsa ntoa khahlanong le tšoaetso e fumanoeng sepetlele.

• Ho ba le kutlo e phahameng: E lemoha ho fihlela ho200 CFU/mL,;
• Sepheo se Nepahetseng: E khetholla hantle C. thatajini ea chefo ea A/B, ho fokotsa lintho tse fosahetseng tse ntle;
• Ho lemoha Pathogen ka ho Otloloha: E sebelisa liteko tsa nucleic acid ho khetholla liphatsa tsa chefo ka ho toba, e theha tekanyetso ea khauta bakeng sa tlhahlobo.
• E lumellana ka botlalo lelisebelisoa tse tloaelehileng tsa PCR tse sebetsanang le lilaboratori tse ngata;

Tharollo ea Mohlala ho Likarabo e hoTeko ea Macro le Micro'sAIO800Lebenkele la PCR la Mobile

Boiketsetso ba Sampole-ho-Araba – Kenya lipeipi tsa sampole tsa mantlha (1.5–12 mL) ka kotloloho, ho felisa ho kenya lipeipi ka letsoho. Ho ntša, ho eketsa le ho lemoha li etsoa ka boiketsetso ka botlalo, ho fokotsa nako ea ho sebetsa le liphoso tsa batho.

• Tšireletso ea Tšilafalo ea Mekhahlelo e 11 – Phallo ea moea e tataisoang, khatello e mpe, ho sefa HEPA, ho bolaea likokoana-hloko ka UV, likarabelo tse koetsoeng, le tšireletso e 'ngoe e kopaneng li sireletsa basebetsi le ho netefatsa liphetho tse tšepahalang nakong ea liteko tse nang le phallo e phahameng.

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