Liphetoho tsa mofuta oa KRAS li ameha mefuteng e mengata ea lihlahala tsa batho, ka sekhahla sa phetoho ea hoo e ka bang 17% -25% ho mefuta eohle ea hlahala, 15% -30% mofetšeng oa matšoafo, le 20% -50% mofetšeng oa mala. Liphetoho tsena li tsamaisa khanyetso ea kalafo le tsoelo-pele ea hlahala ka mochini oa bohlokoa: protheine ea P21 e kentsoeng ke KRAS e sebetsa tlase ho tsela ea matšoao ea EGFR. Hang ha KRAS e fetotsoe, e lula e sebetsa ka mokhoa o sa feleng, e leng se etsang hore litlhare tse lebisitsoeng ho EGFR li se ke tsa sebetsa 'me li lebisa ho ata ha lisele tse kotsi. Ka lebaka leo, liphetoho tsa KRAS li amahanngoa le ho hanyetsa EGFR tyrosine kinase inhibitors mofetšeng oa matšoafo le litlhare tsa anti-EGFR tsa mofetše oa colorectal.

Ka 2008, National Comprehensive Cancer Network (NCCN) e thehile litataiso tsa kliniki tse khothaletsang tlhahlobo ea phetoho ea phetoho ea KRAS bakeng sa bakuli bohle ba nang le mofetše oa metastatic colorectal (mCRC) pele ho kalafo. Litaelo li totobatsa hore boholo ba liphetoho tsa KRAS tse sebetsang li etsahala ho codons 12 le 13 ea exon 2. Ka hona, ho lemoha ka potlako le ka nepo phetoho ea phetoho ea KRAS e bohlokoa bakeng sa ho tataisa phekolo e nepahetseng ea kliniki.

Hobaneng ha tlhahlobo ea CRAS e le Bohlokoa hoMetastaticColorectalCacer(mCRC)

Kankere ea Colourectal (CRC) ha se lefu le le leng empa ke pokello ea li-subtypes tse ikhethileng tsa limolek'hule. Liphetoho tsa KRAS-tse teng hoo e ka bang 40-45% ea bakuli ba CRC-li sebetsa e le "pure" e sa khaotseng, e khothalletsang kholo ea kankere ntle le matšoao a ka ntle. Bakeng sa bakuli ba nang le mCRC, boemo ba KRAS bo lekanya katleho ea li-anti-EGFR monoclonal antibodies tse kang Cetuximab le Panitumumab:

Mofuta o Hlaha oa KRAS:Bakuli ba ka rua molemo kalafong ea anti-EGFR.

KRAS e fetotsoeng:Bakuli ha ba fumane molemo ho tsoa ho baemeli bana, ba ipeha kotsing ea litla-morao tse sa hlokahaleng, litšenyehelo tse eketsehileng, le tieho ea phekolo e sebetsang.

Ka hona, tlhahlobo e nepahetseng le e hlokolosi ea KRAS ke motheo oa moralo oa kalafo oa motho ka mong.

Phephetso ea ho Fumana: Ho qolla Letšoao la Phetoho

Mekhoa ea setso hangata e haelloa ke kutlo bakeng sa liphetoho tse fokolang haholo, haholo lisampong tse nang le hlahala e tlase kapa kamora ho felisoa. Bothata bo teng tabeng ea ho khetholla lets'oao le sa bonahaleng la DNA le feto-fetohang le maemo a holimo a hlaha—joaloka ho fumana nalete mokotleng oa furu. Liphello tse sa nepahalang li ka lebisa tlhokomelong e fosahetseng le liphello tse sekiselitsoeng.

Tharollo ea Rona: E Nepiloe ka ho Fetisisa bakeng sa ho Fumana ho Fetoha ka Kholiseho

KRAS ea rona ea ho lemoha phetoho ea phetoho e kopanya mahlale a tsoetseng pele ho hlola mefokolo ena, e fana ka ho nepahala le ho ts'epahala ho tataiso ea kalafo ea mCRC.

Kamoo Theknoloji ea Rōna e Etsang Hore Mosebetsi o Molemo ka ho Fetisisa

• Theknoloji e ntlafalitsoeng ea ARMS (Amplification Refractory Mutation System): E aha holim'a theknoloji ea ARMS, e kenyelletsang theknoloji ea ntlafatso ea thepa ho eketsa lintlha tse ikhethang.
• Matlafatso ea Enzymatic: E sebelisa li-endonuclease tse thibelang ho cheka boholo ba mofuta o hlaha oa genome ea motho, e boloka mefuta e fetohileng, kahoo e ntlafatsa ho lemoha le ho fokotsa matlafatso e sa khetheheng ka lebaka la semelo se phahameng sa genomic.
• Thibelo ea Mocheso: E hlahisa mehato e ikhethileng ea mocheso ts'ebetsong ea PCR, e bakang ho se lumellane lipakeng tsa li-primers tse feto-fetohang le litempele tsa mofuta o hlaha, ka hona e fokotsa semelo sa mofuta o hlaha le ho ntlafatsa tharollo ea ho lemoha.
• Kutloelo-bohloko e Phahameng: E ​​lemoha ka nepo e ka tlase ho 1% ea DNA e fetotsoeng.
• Ho nepahala ho Haholo: E sebelisa litekanyetso tsa ka hare le enzyme ea UNG ho thibela liphello tse fosahetseng le tse mpe.
• E bonolo ebile e potlakile: E phethela tlhahlobo ka nako e ka bang metsotso e 120, e sebelisa li-tubes tse peli tsa karabelo ho thusa ho lemoha liphetoho tse robeli tse fapaneng, e fana ka sepheo le liphetho tse tšepahalang.
• Tšebelisano ea lisebelisoa: E ikamahanya le lisebelisoa tse fapaneng tsa PCR.

Moriana o nepahetseng oa mofetše oa mala o qala ka tlhahlobo e nepahetseng ea limolek'hule. Ka ho sebelisa KRAS Mutation Detection Kit, laboratoring ea hau e ka fana ka liphetho tse hlakileng, tse sebetsang tse bopang tsela ea kalafo ea mokuli ka kotloloho.

Matlafatsa lab ea hau ka thekenoloji e tšepahalang, e tsoetseng pele — 'me u lumelle tlhokomelo ea motho ka mong.

Iteanye le rona: marketing@mmtest.Com

Ithute haholoanyane mabapi le ho kopanya tharollo ena e tsoetseng pele mosebetsing oa hau oa tlhahlobo.

#Colorectal #Cancer #DNA #Mutation #Precision #Targeted #Kalafo #Kankere

Ho notlolla Precision Medicine ka Kankere ea Colorectal

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