Kankere ea matšoafo e ntse e le sesosa se ka sehloohong sa lefu le amanang le mofets'e lefatšeng ka bophara, kaKankere e Seng e Nyenyane ea Matšoafo ea Lisele (NSCLC) e nkang karolo ea 85% ea linyeoe tsohle.Ka lilemo tse mashome, phekolo ea NSCLC e tsoetseng pele e ne e itšetlehile haholo ka chemotherapy, sesebelisoa se lerootho se fanang ka katleho e fokolang le chefo e kholo.
Phetoho ea kalafo e qalile ka ho sibolloa ha "liphetoho tsa mokhanni" - liphetoho tse khethehileng tsa lefutso tse matlafatsang kholo ea hlahala. Sena se ile sa hlahisa liphekolo tse lebisitsoeng, tse sebetsang e le limisaele tse tataisoang ka nepo, tse senyang lisele tsa mofetše ka mokhoa o ikhethileng ha li ntse li boloka tse phetseng hantle. Leha ho le joalo, katleho ea liphekolo tsena tsa phetoho e itšetlehile ka ho feletseng tlhahlobong e nepahetseng le e tšepahalang ea liphatsa tsa lefutso ho fumana sepheo se nepahetseng bakeng sa mokuli ea nepahetseng.
Li-Biomarker tse Bohlokoa: EGFR, ALK, ROS1, le KRAS
Li-biomarker tse 'ne li eme e le litšiea tlhahlobong ea limolek'hule tsa NSCLC, tse tataisang liqeto tsa pele tsa kalafo:
-EGFR:Phetoho e atileng ka ho fetesisa, haholo ho batho ba Maasia, basali le ba sa tsubeng. EGFR tyrosine kinase inhibitors (TKIs) joalo ka Osimertinib e ntlafalitse liphetho tsa mokuli haholo.
-ALK:"Phetoho ea daemane," e teng ho 5-8% ea linyeoe tsa NSCLC. Bakuli ba ALK fusion-positive hangata ba arabela ka ho teba ho ALK inhibitors, ho finyella bophelo ba nako e telele.
-ROS1:Ho arolelana sebopeho sa sebopeho le ALK, "lehakoe lena le sa tloaelehang" le hlaha ho 1-2% ea bakuli ba NSCLC. Ho na le litlhare tse sebetsang tse lebisitsoeng ho tsona, e leng se etsang hore tlhahlobo ea eona e be ea bohlokoa.
-KRAS:E kile ea nkoa e le "ho sa khonehe," liphetoho tsa KRAS li tloaelehile. Kamohelo ea morao-rao ea KRAS G12C inhibitors e fetotse biomarker ena ho tloha ho lesupa la prognostic ho ba sepheo se ka sebetsoang, ho fetola tlhokomelo bakeng sa sehlopha sena sa bakuli.
The MMT Portfolio: E Entsoe bakeng sa Boitšepo ba Tlhahlobo
Ho fihlela tlhoko e potlakileng ea boitsebahatso bo nepahetseng ba biomarker, MMT e fana ka potefolio ea CE-IVD e tšoailoeng ka nako ea 'nete ea lisebelisoa tsa PCR, e 'ngoe le e 'ngoe e entsoe ka theknoloji e tsoetseng pele ho netefatsa ts'epo ea tlhahlobo.
1. EGFR Mutation Detection Kit
-Theknoloji e ntlafetseng ea ARMS:Li-proprietary enhancers li eketsa matlafatso e khethehileng ea phetoho.
-Matlafatso ea Enzymatic:Li-endonuclease tsa lithibelo li cheka mokokotlo oa mofuta o hlaha, li ntlafatsa tatellano e fetotsoeng le ho ntlafatsa tharollo.
-Thibelo ea Mocheso:Mohato o itseng oa mocheso o fokotsa li-priming tse sa khethollehang, 'me o fokotsa bokapele ba mofuta o hlaha.
-Melemo ea Bohlokoa:Kutloisiso e sa bapisoang ho theosa ho1%mutant allele frequency, ho nepahala ho hoholo ka taolo ea kahare le enzyme ea UNG, le nako ea phetoho e potlakileng ea hoo e ka bang.120 metsotso.
- E lumellana lelisampole tsa biopsy ea lisele le lisele.
2.MMT EML4-ALK Fusion Detection Kit
- Kutloelo-bohloko e Phahameng:E lemoha ka nepo liphetoho tsa fusion ka moeli o tlase oa ho lemoha likopi tse 20 / karabelo.
-Ho nepahala ho Hlollang:E kenyelletsa litekanyetso tsa ka hare bakeng sa taolo ea ts'ebetso le enzyme ea UNG ho thibela tšilafalo ea carryover, ka katleho ho qoba mekhoa e fosahetseng le e fosahetseng.
-E bonolo ebile e potlakile:E na le ts'ebetso e hlophisitsoeng, e koetsoeng e phethiloeng ka metsotso e ka bang 120.
-Tšebelisano ea Lisebelisoa:E lumellana le lisebelisoa tse fapaneng tse tloaelehileng tsa nako ea 'nete tsa PCR, e fanang ka maemo a bonolo bakeng sa ho seta laboratoring efe kapa efe.
3.MMT ROS1 Fusion Detection Kit
Kutloelo-bohloko e Phahameng:E bonts'a ts'ebetso e ikhethang ka ho ts'epahalla ho fumana likopi tse 20/ketso ea sepheo sa fusion.
Ho nepahala ho Hlollang:Tšebeliso ea taolo ea boleng ba kahare le enzyme ea UNG e netefatsa ho ts'epahala ha sephetho se seng le se seng, ho fokotsa kotsi ea ho tlaleha liphoso.
E bonolo ebile e potlakile:Joalo ka sistimi e koetsoeng, ha e hloke mehato e rarahaneng ea kamora ho holisa. Liphetho tse nang le sepheo le tse tšepahalang li fumaneha ka metsotso e ka bang 120.
Tšebelisano ea Lisebelisoa:E etselitsoe hore e tsamaellane ka bongata le metjhini e mengata e tloaelehileng ea PCR, e thusang ho hokahana habonolo ho phallo ea mosebetsi ea lab e teng.
4.MMT KRAS Setsi sa Tlhahlobo ea Phetoho
- Theknoloji e ntlafalitsoeng ea ARMS, e matlafalitsoeng ke Enzymatic Enrichment le Thibelo ea Mocheso.
- Matlafatso ea Enzymatic:E sebelisa li-endonuclease tse thibelang ho cheka sebopeho sa mofuta o hlaha, kahoo e ntlafatsa tatelano e fetotsoeng le ho ntlafatsa tharollo ea ho lemoha haholo.
-Thibelo ea Mocheso:E hlahisa mohato o ikhethileng oa mocheso ho etsa hore ho se lumellane lipakeng tsa li-primers tse ikhethileng le litempele tsa mofuta o hlaha, ho fokotsa maemo a morao-rao le ho ntlafatsa maemo.
- Kutloelo-bohloko e Phahameng:E fihlella kutloisiso ea 1% bakeng sa li-mutant alleles, e netefatsa ho tsebahala ha liphetoho tse fokolang haholo.
-Ho nepahala ho Hlollang:Litekanyetso tse kopaneng tsa kahare le ts'ireletso ea enzyme ea UNG khahlano le liphetho tse fosahetseng le tse mpe.
-Phanele e felletseng:E hlophisitsoe hantle ho thusa ho fumana liphetoho tse robeli tse ikhethileng tsa KRAS ho li-tubes tse peli feela tsa karabelo.
- E bonolo ebile e potlakile:E fana ka sepheo le liphetho tse tšepahalang ka nako ea metsotso e ka bang 120.
- Tšebelisano ea Lisebelisoa:E ikamahanya hantle le lisebelisoa tse fapaneng tsa PCR, e fana ka maemo a fapaneng bakeng sa lilaboratori tsa bongaka.
Hobaneng o Khetha Tharollo ea MMT NSCLC?
Kakaretso: Kakaretso e felletseng bakeng sa li-biomarker tse 'ne tsa bohlokoahali tsa NSCLC.
Theknoloji e Phahameng ka ho Fetisisa: Lintlafatso tsa Theknoloji (Enzymatic Enriching, Thibelo ea Mocheso) li netefatsa boits'oaro bo phahameng le kutloisiso moo ho leng bohlokoa haholo.
E potlakile ebile e sebetsa hantle: Protocol ea Uniform ~ metsotso e 120 ho pholletsa le potefolio e potlakisa nako ea ho ea kalafo.
Flexible & Accessible: E lumellana le mefuta e mengata ea mehlala le lisebelisoa tse tloaelehileng tsa PCR, ho fokotsa litšitiso tsa ts'ebetsong.
Qetello
Nakong ea oncology e nepahetseng, tlhahlobo ea limolek'hule ke sesupa-tsela se tataisang ho tsamaea ha kalafo. Lisebelisoa tsa ho lemoha tse tsoetseng pele tsa MMT li matlafatsa baoki ho etsa 'mapa oa liphatsa tsa lefutso tsa NSCLC ea mokuli ka boits'epo, e leng ho bula monyetla oa ho pholosa bophelo oa liphekolo tse lebisitsoeng.
Contact to learn more: marketing@mmtest.com
Nako ea poso: Oct-14-2025