Sebetsa se secha sa tlhahlobo ea lefuba ea lefutso le ho hanyetsa litlhaselo tse ncha tsa lithethefatsi: Teng e nchafalitsoeng (Tngs) e kopantsoeng le mochini oa ho ithuta ka mochini oa lefutso oa lefutso
Tlaleho ea lingoliloeng: CCC: Tlhahlobo e fetotsoeng ea tšobotsi e thehiloeng li-tings le ho ithuta batho le lefu la lefuba tse nang le lefu la lefutso.
Thesis Thesis: Leqheka la thuto ea Tuberculaus le ile la fumana ho ithuta le ho ithuta ka mechine ea ho ithuta ka matichere.
Nako: "Clinica chibica Actal"
Haeba: 6.5
Letsatsi la phatlalatso: Pherekhong 2024
E kopantsoe le Univesithi ea Sechaba sa Machaena sa Sehlekehleke sa Spain le Beijing Seteishene sa Tlhahlobo ea Mahlale Ho lemoha kutloisiso ea lefuba le nang le libaktheria tse fokolang le mesiningtis ea lefutso, e fane ka mokhoa o mocha oa ho hlalosa mokhoa o mocha oa ho pepesoa Ho hlahloba mefuta e 'meli ea lefuba ea lefuba,' me u thusitse phepelo e nepahetseng, ho khetholloa lithethefatsi le kalafo ea lefutso. Ka nako e ts'oanang, ho fumanoe hore plasma ea mokuli Cfdna e ka sebelisoa e le mofuta o loketseng oa mohlala oa boloi ba bongaka maemong a tbm.
Thutong ena, li-sampole tse 227 le sampole ea Clasma tsa Cohor tsa Clobers tsa Clinical Inform, moo ho ile ha sebelisoa mehlala ea li-tuberculosis, 'me sampole ea li-lefutso tsa lefutso e ne e sebelisoa ho netefatsa ho netefatsoa Moetso oa tlhahlobo. Mehlala eohle e ile ea shejoa ke Letamo le hlophiselitsoeng la Probed Disved Contidence bakeng sa lefu la mycobacterium. Ka mor'a moo, ho ipapisitse le data ea tatellano ea lefuba, mohlala oa tlhahlobo o sebelisetsoang ho etsa tlhahlobo ea liseele tse 5 tsa tlhahlobo ea li-samonttic le sesebelisoa sa creabropinal se fumanoang. Monyako o fumanoeng o tlisoa ka tatellano ea tlhahlobo ea tlhahlobo ea bongaka ea ho bona, 'me ts'ebetso ea tlhahlobo ea bongaka ea seithuti e ntse e hlahlojoa ke roc curve. Qetellong, mofuta oa khethollo ea lefutso la lefuba o ile oa fumanoa.
Feiga 1 litlhahlobo tsa moralo oa moralo oa lipatlisiso
Liphetho: Ho ea ka monyako o ikhethang oa CSF DNA SAMPLE (AUC = 0.974) le sampole ea 227, ho ne ho le joalo, ka ho hlaka e ne e le 95.65%, le Sensitivity le Tumple sampole ea plasma e ne e le 82.61% le 86.36%. Ha ho hlahlojoa li-sampole tse 44 tsa li-dfdna tsa plasma tsa Plasma tsa Plasma tsa CFDNA le Bakuli ba Tlhaho (42/44). Ho bana ba nang le lefuba la likhoele, lefu la ho hlahloba thuto ena ho ameha ka li-dempole tsa plasma ho feta bakuli ba ka mpeng (28,57%.
Feiga ea 2 ea ho sekaseka ha motho ea tloaetseng ho etsa mohlala oa li-sampole tsa baahi
Feiga e hlahisoang ke li-stufnostic tsa lipelaelo tse pakiloeng
Sephetho: Mokhoa oa ho fetoha ha Hypensetive oa Hypensetisi o thehiloe thutong ena, e ka fanang ka sesebelisoa sa bolumeli se phahameng ka ho fetisisa sa bakuli ba hooa ba nang le lefuba la enliniki ka ho fetisisa (setso se fosahetseng). Ho lemoha lefu la Hypersculon ho ipabola plasma Cfdna e ka ba ntho e loketseng ea lefuba le nang le lefu la litsietsi le bakuli ba belaelloang.
Khokahano ea mantlha: Fortos://www.Sciencedirect.com/science/Poii/s0009898300490? Via% 3dihub
TLHOKOMELISO EA MAMRO & Micro-Testculosis Lihlahisoa tsa Lehloeo
Ka lebaka la boemo bo rarahaneng ba mohlala o rarahaneng oa bakuli le litlhoko tse fapaneng, tlhahlobo e felletseng ea li-NGSCTic, laeborari ea laeborari le tatellano ea chelete. Lihlahisoa li koahela ho ts'oaroa ha bakuli ba lefupelo, ho ala litlhaselo tsa Mycobactesis le NTM, Hypensenity ea batho ba nang le lefuba le lefu la lefuba, jj.
Li-kits tsa ho lemosoa ha lefu la lefutso le Mycobacter:
| Ntho Che | Lebitso la Product | Likahare tsa Sehlahisoa | Mofuta oa sampole | Mohlala o Sebetsa |
| HWTS-3012 | Mohlala oa Thuso ea Molisa | E sebelisoa ho kalafo ea lisato tsa sputum, e fumane nomoro ea rekoto ea Class, lisebelisoa tsa mochini oa StoTong 20230047. | Sputum | |
| HWTS-NGS-P00021 | Kitcomm ea palo ea "SULPCOM CIT bakeng sa Hypensensitive Tuberculosis (probe mokhoa oa ho ts'oaroa) | Sesebelisoa se sa khaotseng (metsi Biopsy) a ho khetholloa bakeng sa hypersension bakeng sa libaktheria tse mpe tsa boea le li-nodule tsa boko; Mehlala ea batho e belaelloang hore e tšoaelitsoe ke lefuba la Mycobacteria le e bonang ka har'a lithethefatsi tsa mofuta leha e le lefu la mokokotlo oa lamunu ea mycobactesim li ile tsa fanoa. | Mali a Sipolonte, Albolar Lavage Frieid, Hydrothorax le Ascites, ho tsepamisa maikutlo sampole, mokelikeli oa Cerebropinal. | Moloko oa bobeli |
| HWTS-NGS-T001 | Kit ea Mycobacterium Typium Kit ea ho e sebelisa e sa sebetseng ea lithethefatsi (Mokhoa oa ho qala oa Bohlokoa) | Teko ea Mycobacterium Typium, ho kenyelletsa MTBC le 187 NTM;Ho khetholloa ha lithethefatsi tsa Mycobacterium ho akaretsa lithethefatsi tse 25 le likarolo tsa 16 tsa liphatsa tsa tsipiso ea lithethefatsi. | Sputum, Alvolar Lavage Frieid, Hydrothorax le Ascites, ho tsepamisa maikutlo sampole ea CUTCTUR, Cerebropinal. | Sekhechana sa bobeli / sa boraro moloko oa boraro oa boraro |
Lintlha-khōlō: HPSts-NGS-T001 Mycobacterium Typium Kit ea ho e sebelisa e sa sebetseng ea lithethefatsi (mokhoa oa ho ngola libuka)
Selelekela sa Product
Sehlahisoa se thehiloe ho lithethefatsi tse kholo tsa pele le tsa bobeli tse hlalositsoeng ho tse tataisang lefung tsa lefu la lefumo, le libaka tsa kalafo tsa kalafo tse koahelang sehlopha sohle sa libaka tse amanang le lithethefatsi tse amanang le lithethefatsi ho Who Ibercuaccilosium Teatation ea Mycobacciuf, hammoho le tse ling tsa liphatsa tsa pherekano le libaka tsa phetoho ho latela lipatlisiso le mose ho masene.
Ho thaepa ho khethoa ho ipapisitse le lipapatso tsa NTM tse akaretsoang ka litataiso tsa NTM tse hatisitsoeng ke mafu a china le phokolo ea phefumoloho le tumellano ea litsebi. Li-gangyers tse entsoeng ka thapo li ka holisa, tatellano le ho bua le mofuta o fetang 190 ntm.
Ka theknoloji ea theknoloji e hapiloeng e lebisitsoeng, liphatsa tsa lefutso tse amanang le lithethefatsi tsa lithethefatsi li ne li angoa ka mokhoa o khethiloeng oa liphatsa tsa lefutso tse fumanoeng. Lihlahisoa tsa Amplified li ka hahuoa ho tsoa mokhatlong oa bobeli kapa melokong eohle ea karolo ea boraro le meralo eohle ea mela ea morao-rao e ka fuoang tlhaiso-leseling ea liphallelo tsa lefutso. Ka ho bapisa le liphetoho tse tsebahalang tse fumanehang ka database ea litšupiso e hahiloeng (ho kenyeletsoa lethathamong la litšupiso tsa li-turcobaccilium le kamano e amanang le litlhare tsa lithethefatsi E kopantsoe le tharollo ea kalafo ea sputum e ntlafalitsoeng ea tlhahlobo ea macro e bulehileng e sebelisitsoe ka kotloloho ho disampm tsa sputum.
Boemo ba ho lemoha sehlahisoa
34Mefuta e amanang le lithethefatsi e amanang le lithethefatsi18Lithethefatsi tsa Anti-lefutso6Lithethefatsi tsa NTM li fumanoe, ho koaheloa297libaka tsa bohanyetsi tsa lithethefatsi; Mefuta e leshome ea li-tuberculosium tsa mycobacterium le tse fetang190mefuta ea NTM e fumanoe.
Lethathamo la 1: Tlhahisoleseling ea 18 + 6 Lithethefatsi + 30 + NTM
Molemong oa sehlahisoa
Ho ikamahanya le maemo a matla: Mehlala ea sputum e ka fumanoa ka kotloloho le moemeli oa baitellite ntle le setso.
Ts'ebetso ea liteko e bonolo: Ts'ebetso ea ho qala pele e bonolo, 'me kaho ea laebrari e phethoa ka lihora tse 3, e ntlafatsang ts'ebetso ea mosebetsi.
Ho hanyetsa ho tšoaea liphoso le ho sebelisa lithethefatsi hantle: Ho nka libaka tse loantšanang le ho hanyetsa lintlha tse nepahetseng tsa tlhahlobo le tlhaiso ea tlhahlobo e le 'ngoe.
Ho lumellana: Ho tsamaisana le Lihlahisoa
Tlhaloso ea sehlahisoa
| Khoutu ea sehlahisoa | Lebitso la Product | Sethala sa ho lemoha | Litlhaloso |
| HWTS-NGS-T001 | Kit ea Mycobacterium Typium Kit ea ho e sebelisa e sa sebetseng ea lithethefatsi (Mokhoa oa ho ngolisa oa multiplex | Ont, Ilmina, MGI, Salus Pro | 16 / 96rxn |
Nako ea poso: Jan-23-2024