Mofuta o sa tsoa hlaha oa ntaramane—Mokhohlane oa A(H3N2) Subclade K—e khanna ts'ebetso e phahameng ka mokhoa o sa tloaelehang ea ntaramane libakeng tse ngata, e beha khatello e kholo lits'ebetsong tsa tlhokomelo ea bophelo lefatšeng ka bophara. Ka nako e ts'oanang, mekhoa e mecha ea tlhahlobo ea mafu e qala ho tloha hotlhahlobo e potlakileng ea antigenhotlhahlobo ea limolek'hule e iketsang ka botlalohotatellano e felletseng ea liphatsa tsa lefutsoli fetola tsela eo re lemohang, re tiisang le ho utloisisa litšokelo tse ntseng li fetoha tsa vaerase.
Hammoho, ntshetsopele tsena di tshwaya phetoho e lebisang mokgweng o nepahetseng le o nang le dikarolo tse ngata wa taolo ya mafu a tshwaetsanang a phefumoloho.
Mofuta o Fetolang Papali: Ke Eng e Etsang Hore Subclade K e Fapane?
Subclade Ke emela lekala le sa tsoa fetoha la liphatsa tsa lefutso ka har'a leloko la H3N2, le bōpiloeng ke liphetoho tse tsoelang pele protheineng ea hemagglutinin (HA). Leha ho lebeletsoe ho falla ha antigenic, Subclade K e ikhethile ka potlako ka litšobotsi tse peli tsa bohlokoa:
Ho Pholoha ha 'Mele oa ho Sireletsa
Liphetoho tsa bohlokoa tsa HA li fetola boemo ba antigen ba vaerase, li fokotsa ho tšoana ha eona le:
-Mefuta e kenyelelitsoeng lienteng tsa ntaramane tsa hona joale
-Sesole sa 'mele se hahiloeng ka lebaka la tšoaetso ea morao tjena
Sena se fella ka sekhahla se phahameng sa tšoaetso e tsoelang pele.
Boikoetliso bo Ntlafalitsoeng ba Phetiso
Liphetoho tsa sebopeho li ka ntlafatsa bokhoni ba vaerase ba ho hokahana le li-receptor tse karolong e ka holimo ea phefumoloho, e leng se fang Subclade K monyetla oa tlholisano phetisong.
Tšusumetso ea Lefatše
Lintlha tsa tlhokomelo tse tsoang linaheng tsa Asia le Europe li bontša hore Subclade K e ikarabella bakeng saho feta 90%tsa ho fumanoa ha H3N2 haufinyane. Ho ata ha eona ka potlako ho kentse letsoho linakong tsa pele tsa ntaramane le moroalo o eketsehileng oa tlhokomelo ea bophelo, ho totobatsa tlhoko ea maano a ho lemoha a fapaneng a etselitsoeng libaka tsa bongaka, tsa sechaba le tsa bophelo bo botle ba sechaba.
Moralo oa Tlhahlobo ea Maemo a Mararo bakeng sa Subclade K
Mofuta oa ntaramane o fetohang ka potlako o hlokaleano la tlhahlobo le nang le maemo a fapaneng, le tlatsanange nolofalletsang:
-Tlhahlobo e potlakileng libakeng tsa sechaba
-Tiisetso e potlakileng le e nepahetseng maemong a bongaka
-Tlhahlobo e tebileng ea liphatsa tsa lefutso bakeng sa tlhokomelo le lipatlisiso
Ka tlase ke moralo o kopaneng oa litharollo tse tharo.
1.Tlhahlobo e Potlakileng:e tenyetsehang 2~6-in-1Teko ea Antigen (Immunochromatography)
E loketse bakeng sa:
Litliliniki tsa tlhokomelo ea mantlha, mafapha a bakuli ba sa eeng sepetlele, likamore tsa bophelo bo botle tsa sekolo, litliliniki tsa sebaka sa mosebetsi, le liteko tsa lapeng.
Hobaneng ho le bohlokoa:
Litlhophiso tsena li hloka tlhahlobo ea hang-hang le liqeto tse potlakileng ho thibela ho ata le ho tataisa mehato e latelang.
Likarolo tsa Bohlokoa:
-Ts'ebetso e bonolo, e se nang lisebelisoa
-Liphetho li fumaneha hoMetsotso e 15
E nolofalletsa ho lemoha kapele tšoaetso ea Influenza A le B kapa tšoaetso e 'ngoe e tloaelehileng ea ho hema.
Teko ena e bopamola oa pele oa ho lemoha boemo ba sechaba, ho thusa ho lemoha ka potlako linyeoe tse belaelloang le ho fumana hore na ho hlokahala netefatso ea limolek'hule.
1.Netefatso e Potlakileng ea Limolek'hule: AIO800 e Iketsetsa ka BotlaloLimolek'huleSistimi ea ho lemoha+ Sete ea ho lemoha ho hema ea 14-in-1
E loketse bakeng sa:
Mafapha a tšohanyetso a sepetlele, liphaposi tsa bakuli ba ka hare, litleliniki tsa feberu, le lilaboratori tsa tlhahlobo ea mafu tsa libaka.
Hobaneng ho le bohlokoa:
Ka lebaka la ho phonyoha ha sesole sa 'mele sa Subclade K le ho kopana ha matšoao le likokoana-hloko tse ling tsa ho hema, ho tsebahatsa ka nepo ho bohlokoa bakeng sa:
-Ho etsa qeto ka kalafo ea antiviral e kang oseltamivir
-Ho khetholla ntaramane ho tsoa ho RSV, adenovirus, kapa likokoana-hloko tse ling
-Ho etsa liqeto tse potlakileng tsa ho kena sepetlele kapa ho itšehla thajana
Likarolo tsa Bohlokoa:
-Mosebetsi oa 'nete oa "ho kenya mohlala, sephetho" o iketsang ka botlalo
-E fana ka liphetho tsa teko ea nucleic acid hoMetsotso e 30–45
-Liphanele tsa PCR tsa nako ea sebele tse ngata lia lemoha14likokoana-hloko tsa phefumolohoesita le ha mojaro oa vaerase o le tlase haholo.
AIO800 e sebetsa e lemotheo oa klinikiea tlhahlobo ea ntaramane ea sejoale-joale, e nolofalletsang netefatso e potlakileng le e nepahetseng le ho tšehetsa tlhokomelo ea bophelo bo botle ba sechaba ka nako ea sebele.
3. Patlisiso e Tebileng ea Vaerase: Tatellano e Felletseng ea Livaerase tsa Influenza
E loketse bakeng sa:
Litsi tsa Taolo ea Mafu, litsi tsa lipatlisiso, libaka tsa tlhokomelo ea vaerase, le lilaboratori tsa bophelo bo botle ba sechaba tsa naha kapa tsa libaka.
Hobaneng ho le bohlokoa:
Subclade K—le mefuta e meng ya nakong e tlang—e lokela ho behwa leihlo ka ho tswela pele boemong ba genome ho utlwisisa:
- Ho kheloha ha antigenic
-Liphetoho tsa ho hanyetsa vaerase
-Ho hlaha ha mefuta e mecha
-Marang-rang a phetisetso le tšimoloho ea seoa
Likarolo tsa Bohlokoa:
-Tšebeletso ea ho tloha qetellong ho isa qetellong ho tloha ho ntšoeng ha sampole ho ea ho lokisoeng ha laeborari, tatellano, le tlhahlobo ea bioinformatic
-E fana ka tatellano e felletseng ea liphatsa tsa lefutso tsa vaerase
-E nolofalletsa tlhahlobo ea liprofaele tsa phetoho ea lefutso, lifate tsa phylogenetic, le matla a ho iphetola ha lintho
Ho latellana ha liphatsa tsa lefutso tse felletseng ho emelalera le tebileng ka ho fetisisa la tlhahlobo, ho fana ka temohisiso e thusang ho ntlafatsa liente, liqeto tsa leano, le lefats'e ka bophara
meralo ea tlhokomelo.
Ho ea ho Sistimi ea Taolo ea Feberu e Laoloang ka ho Sebetsa ka ho Nepahetseng
Motsoako oa tšokelo ea vaerase e fetohang ka potlako le mahlale a tsoetseng pele a tlhahlobo ea mafu a tšoaetsanoang a baka phetoho leanong la bophelo bo botle ba sechaba.
1. Ho tloha ho Khakanyo e Thehiloeng ho Matšoao ho ea ho Teko e Nepahetseng ea Mealo
Tlhahlobo ea antigen → netefatso ea limolek'hule → ho latela liphatsa tsa lefutso ho theha mothapo o felletseng oa tlhahlobo.
2. Ho tloha ho Karabelo e Amohelang ho ea ho Tlhokomeliso ea Nako ea Sebele
Teko e potlakileng khafetsa le data ea genomic e tsoelang pele e tšehetsa litemoso tsa pele le phetoho e matla ea leano.
3. Ho tloha Mehatong e Arohaneng ho ea ho Taolo e Kopantsoeng
Ho enta, ho hlahloba ka potlako, kalafo ea antiviral, le mekhoa ea bophelo bo botle ba sechaba li theha tsamaiso e kopanetsoeng ea tšireletso.
Ka har'a moralo ona, teko ea antigen e fana kasefe sa mola o ka pele, AIO800 e fana kaho nepahala ha bongaka, le litlhahiso tsa tatellano e felletseng ea liphatsa tsa lefutsobotebo ba leano—mmoho ba theha tšireletso e matla ka ho fetisisa khahlanong le Subclade K le mefuta e meng ea ntaramane ea nakong e tlang.
Nako ea poso: Tshitwe-10-2025