Demystifying Influenza A(H3N2) Subclade K le Diagnostic Revolution Shaping Sejoale-joale Taolo ea Mafu.

Mofuta o mocha oa ntaramane—Influenza A(H3N2) Subclade K-e khanna ts'ebetso ea ntaramane e phahameng ka mokhoa o sa tloaelehang libakeng tse ngata, e beha khatello e kholo lits'ebetsong tsa bophelo bo botle ba lefats'e. Ka nako e ts'oanang, mekhoa e mecha ea ho hlahloba ho tloha hotlhahlobo e potlakileng ea antigenhotlhahlobo ea limolek'hule ka botlalohotatellano ya genome e felletsengre fetola tsela eo re lemohang ka eona, re tiisang le ho utloisisa litšokelo tsa kokoana-hloko.

Ka kopanelo, lintlafatso tsena li tšoaea phetoho e lebisang mokhoeng o nepahetseng haholoanyane oa taolo ea mafu a tšoaetsanoang a phefumoloho.

Phapang e Fetola Papali: Ke Eng e Etsang Hore Subclade K e fapane

Subclade Ke emela lekala la liphatsa tsa lefutso tse sa tsoa fetoha ka har'a leloko la H3N2, le entsoeng ka liphetoho tse tsoelang pele ho protheine ea hemagglutinin (HA). Leha ho lebeletsoe hore ho hoholehe ha antigenic, Subclade K e ikhetholla ka potlako ka thepa e 'meli ea bohlokoa:

Ho Pholoha ha 'mele

Liphetoho tsa bohlokoa tsa HA li fetola boemo ba kokoana-hloko ea antigenic, e fokotsa ho tšoana ha eona le:

-Mathata a kenyellelitsoeng lienteng tsa hona joale tsa ntaramane

-Itšireletseho e hahiloeng ho tsoa ho mafu a morao-rao

Sena se fella ka sekhahla se phahameng sa ts'oaetso ea katleho.

Phetiso e Matlafalitsoeng

Liphetoho tsa sebopeho li ka ntlafatsa bokhoni ba kokoana-hloko ea ho tlama li-receptors tse karolong e ka holimo ea phefumoloho, tsa fa Subclade K monyetla oa tlholisano phetisong.

Tšusumetso ea Lefatše

Lintlha tsa boithuto tse tsoang linaheng tsa Asia le Europe li bonts'a Subclade K accounting bakeng saho feta 90%ea litlhahlobo tsa morao-rao tsa H3N2. Ho ata ha eona ka potlako ho kentse letsoho linakong tsa pele tsa feberu le ho eketsa moroalo oa tlhokomelo ea bophelo bo botle, ho totobatsa tlhoko ea maano a fapaneng a ho lemoha a ipapisitseng le maemo a bophelo bo botle ba sechaba, a sechaba le a sechaba.

Moralo oa Tlhahlobo oa Mekhahlelo e meraro bakeng sa Subclade K

Mofuta o mong oa ntaramane o fetohang ka potlako o hloka homaqheka, leano le tlatsanang la tlhahloboe thusang:

-Tlhahlobo e potlakileng libakeng tsa sechaba

-Tiiso e potlakileng, e nepahetseng maemong a kliniki

-Deep genomic analysis bakeng sa ho beha leihlo le ho etsa lipatlisiso

Ka tlase ke moralo o kopantsoeng oa tharollo e meraro.

1.Tlhahlobo e potlakileng:tenyetseha 2~6-in-1Teko ea Antigen (Immunochromatography)

E loketse:
Litleliniki tsa tlhokomelo ea mantlha, mafapha a bakuli ba kantle ho naha, likamore tsa bophelo tsa sekolo, litleliniki tsa mosebetsing, le ho itlhahloba malapeng.

Hobaneng ho le bohlokoa:
Litlhophiso tsena li hloka ho lekoa hang-hang le liqeto tse potlakileng ho thibela ho ata le ho tataisa mehato e latelang.

Likarolo tsa Bohlokoa:

-Ts'ebetso e bonolo, ntle le lisebelisoa

-Liphetho li fumaneha hoMetsotso e 15

E thusa ho tsebahatsa tšoaetso ea Influenza A & B kapa mafu a mang a atileng haholo a ho hema.

Teko ena e thehamokhoa oa pele oa ho lemoha boemo ba sechaba, ho thusa ho lemoha kapele linyeoe tse belaelloang le ho fumana hore na ho hlokahala tiiso ea limolek'hule.

1.Tiisetso e Potlakileng ea Limolek'hule: AIO800 e Ikemetseng ka BotlaloMolek'huleSistimi ea ho tseba+14-in-1 Setho sa ho Fumana Phefumoloho

E loketse:
Mafapha a tšohanyetso a sepetlele, liphaposi tsa bakuli, litleliniki tsa feberu, le lilaboratori tsa libaka tsa tlhahlobo ea mafu.

Hobaneng ho le bohlokoa:
Ka lebaka la phonyoha ea 'mele ea ho itšireletsa mafung ea Subclade K le ho kopana ha matšoao le likokoana-hloko tse ling tsa phefumoloho, boitsebahatso bo nepahetseng bo bohlokoa bakeng sa:

-Ho etsa qeto ka kalafo ea antiviral joalo ka oseltamivir

- Ho khetholla ntaramane ho tsoa ho RSV, adenovirus, kapa likokoana-hloko tse ling

-Ho etsa liqeto tse potlakileng tsa ho kena sepetlele kapa ho itšehla thajana

Likarolo tsa Bohlokoa:

-Tlhahiso ea 'nete ea "sample-in, result-out" e itirisang ka botlalo

- E fana ka liphetho tsa tlhahlobo ea nucleic acid30–45 metsotso

- Liphanele tsa PCR tsa nako ea nnete tse ngata li lemoha14likokoana-hloko tsa ho hemaesita le maemong a tlase haholo a bongata ba kokoana-hloko.

AIO800 e sebetsa e le sesebelisoa sasetsi sa klinikiea tlhahlobo ea ntaramane ea sejoale-joale, e nolofalletsang netefatso e potlakileng, e nepahetseng le ho ts'ehetsa tlhahlobo ea nako ea nnete ea bophelo bo botle ba sechaba.

3. Patlisiso e tebileng ea kokoana-hloko: Tatelano ea Genome e Felletseng ea Likokoana-hloko tsa Influenza

E loketse:
Litsi tsa Taolo ea Mafu, litsi tsa lipatlisiso, libaka tsa tlhahlobo ea vaerase, le lilaboratori tsa naha kapa tsa tikoloho tsa bophelo bo botle ba sechaba.

Hobaneng ho le bohlokoa:
Subclade K-le mefuta e fapaneng ea nako e tlang-e tlameha ho beoa leihlo khafetsa maemong a genomic ho utloisisa:

- Ho hoholeha ha antigenic

- Liphetoho tsa antiviral resistance

- Ho hlaha ha mefuta e mecha

- Marang-rang a phetiso le tšimoloho ea seoa

Likarolo tsa Bohlokoa:

-Tshebeletso ea ho qetela ho tloha ho qotsulo ea mohlala ho ea ho boitokiso ba laeborari, tatellano, le tlhahlobo ea bioinformatic

-E fana ka tatelano e felletseng ea kokoana-hloko ea genome

-E thusa ho hlahloba litlaleho tsa phetoho ea phetoho, lifate tsa phylogenetic, le matla a ho iphetola ha lintho

Tatelano ea liphatsa tsa lefutso ka botlalo e emelalera la tlhahlobo le tebileng ka ho fetisisa, e fanang ka lintlha tse tsebisang lintlafatso tsa ente, liqeto tsa leano, le lefats'e
liforeimi tsa ho beha leihlo.

Ho ea ho Sistimi ea Taolo ea Mokollane e Tsamaoang ka nepo

Motsoako oa tšokelo ea kokoana-hloko e ikamahanyang ka potlako le mekhoa e tsoetseng pele ea tlhahlobo e tsamaisa phetoho leanong la bophelo bo botle ba sechaba.

1. Ho tloha ho Guesswork e thehiloeng ho Matšoao ho ea ho Precision Layered Testing

Tlhahlobo ea antigen → netefatso ea limolek'hule → ho latela genomic ho theha phaephe e felletseng ea tlhahlobo.

2. Ho tloha ho Reactive Response to Real-Time Awareness

Teko ea khafetsa e potlakileng le data e tsoelang pele ea genomic e tšehetsa litemoso tsa pele le tokiso e matla ea leano.

3. Ho tloha Mehatong e Khaohileng ho ea ho Taolo e Kopanetsoeng

Ente, tlhahlobo e potlakileng, kalafo e thibelang kokoana-hloko, le litšebelisano tsa bophelo bo botle ba sechaba li theha tsamaiso e hokahaneng ea ts'ireletso.

Ka har'a moralo ona, tlhahlobo ea antigen e fana kafilthara e ka pele, AIO800 ea fanaho nepahala ha bongaka, le litefiso tse felletseng tsa tatellano ea liphatsa tsa lefutsobotebo ba leano-hammoho ho theha tšireletso e matla ka ho fetisisa khahlanong le Subclade K le mefuta e meng ea ntaramane e tlang.