Lefu la myelogenousleukemia le sa foleng (CML) ke lefu le kotsi la clonal la lisele tsa hematopoietic stem. Bakuli ba fetang 95% ba CML ba na le chromosome ea Philadelphia (Ph) liseleng tsa bona tsa mali. Mme gene ea fusion ea BCR-ABL e thehoa ke translocation pakeng tsa ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) letsohong le lelelele la chromosome 9 (9q34) le gene ea breakpoint cluster region (BCR) letsohong le lelelele la chromosome 22 (22q11). Protheine ea eona ea fusion e kentsoeng ke gene ena e na le ts'ebetso ea tyrosine kinase (TK), 'me e kenya tšebetsong litsela tsa eona tsa lipontšo tse theohelang (joalo ka RAS, PI3K, le JAK/STAT) ho khothaletsa karohano ea sele le ho thibela apoptosis ea sele, e leng se etsang hore lisele li ate ka mokhoa o kotsi, 'me ka hona li baka ho hlaha ha CML.
Jini ea motsoako oa BCR-ABL, e leng ea bohlokoa nts'etsopele ea CML, e sebetsa e le letšoao la bohlokoa la tlhahlobo. ea CML. Ho fumanoa ha eona ho thusa ho beha mokuli leihlo'Karabelo ea s ho li-inhibitor tsa tyrosine kinase (TKIs) le ho bolela esale pele hore leukemia e tla khutla hape, e leng ntho ea bohlokoa bakeng sa taolo e sebetsang ea bakuli ba CML.
BCR-ABL ea MothoKiti ea ho Fumana Phetoho ea Liphatsa tsa Lefutso la Fusionho tsoa ho Macro & Micro-Test bakeng sa ho lemoha BCR-ABL ka boleng ho bakuli ba CML, e thusa tlhahlobo ea CML le ho tataisa mekhoa ea phekolo ea bongaka e reretsoeng ho ntlafatsa maano a kalafo bakeng sa taolo e sebetsang ea bakuli. BCR-ABL fusion gene, e lengkebohlokoantshetsopeleng ya CML,e sebetsa e le letšoao la bohlokoa la tlhahloboofCMLHo lemoha ha eona ho thusa hosekirinimokuli'sKarabelo ho li-inhibitor tsa tyrosine kinase (TKIs)lee bolela esale pele ho khutla ha leukemia, e lengbohlokoato e sebetsa hantleCMLtsamaiso ea bakuli.
Kiti ea ho Fumana Phetoho ea Liphatsa tsa lefutso tsa BCR-ABL ea Motho ho tsoa ho Macro & Micro-Test bakeng sa ho lemoha BCR-ABL ka boleng ho bakuli ba CML, lithusoCMLtlhahlobo ea lefubalebatataisimekhoa ea phekolo e reretsoeng ea bongakatooptimizemaano a phekolo bakeng sa taolo e sebetsang ea mokuli.
E akaretsangDtlhahlobo:Ka nako e le 'ngoeho lemohabakeng sa3liphatsa tsa lefutso tse tloaelehileng tsa ho kopanya (P210, P190, P230)bakeng saho akaretsa ka bophara lethibelo ea linyeoe tse fositsoeng;
Ho ba le kutlo e phahameng:Mofuta oa mokelikeli o lemoha liphatsa tsa lefutso tsa ho kopanaka LoDea likopi tse 1000/mL,le mofuta oa lyophilizedof Likopi tse 500/mL;
E babatsehangAho nepahala: Iea ka haretaolole enzyme ea UNG ho thibela lintho tse fosahetseng tse ntle& lintho tse mpe;
Ho Sebelisa Habonolo le Bokgoni:Ts'ebetso ea tube e koetsoeng,ha e na lihlahisoakamora ho sebetsoa,leho lemohaka hare hoMetsotso e 60bakeng saliphetho tse se nang leeme le tse tšepahalang;
HapeDikgetho：Mefuta e metsi le e lyophilized bakeng sa dikgetho tsa bareki;
Ho lumellana ho pharaletseng:E lumellana le litsamaiso tse ngata tsa PCR bakeng sa phihlello e pharaletseng ea laboratori.
E akaretsangDtlhahlobo:Ka nako e le 'ngoeho lemohabakeng sa3liphatsa tsa lefutso tse tloaelehileng tsa ho kopanya (P210, P190, P230)bakeng saho akaretsa ka bophara lethibelo ea linyeoe tse fositsoeng;
Ho ba le kutlo e phahameng:Mofuta oa mokelikeli o lemoha liphatsa tsa lefutso tsa ho kopanaka LoDea likopi tse 1000/mL,le mofuta oa lyophilizedof Likopi tse 500/mL;
E babatsehangAho nepahala: Iea ka haretaolole enzyme ea UNG ho thibela lintho tse fosahetseng tse ntle& lintho tse mpe;
Ho Sebelisa Habonolo le Bokgoni:Ts'ebetso ea tube e koetsoeng,ha e na lihlahisoakamora ho sebetsoa,leho lemohaka hare hoMetsotso e 60bakeng saliphetho tse se nang leeme le tse tšepahalang;
HapeDikgetho：Mefuta e metsi le e lyophilized bakeng sa dikgetho tsa bareki;
Ho lumellana ho pharaletseng:E lumellana le litsamaiso tse ngata tsa PCR bakeng sa phihlello e pharaletseng ea laboratori.
Nako ea poso: Mots'eanong-16-2024