Chronic myelogenousleukemia (CML) ke lefu le kotsi la clonal la lisele tsa stem tsa hematopoietic. Ho feta 95% ea bakuli ba CML ba na le chromosome ea Philadelphia (Ph) liseleng tsa bona tsa mali. 'Me mofuta oa BCR-ABL oa fusion o thehoa ke phetoho pakeng tsa ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) letsohong le lelelele la chromosome 9 (9q34) le sebaka sa breakpoint cluster region (BCR) sephakeng se selelele sa chromosome 212 (22q12). Protheine ea eona ea fusion e kentsoeng ke mofuta ona e na le ts'ebetso ea tyrosine kinase (TK), 'me e kenya tšebetsong litsela tsa eona tse tlase (tse kang RAS, PI3K, le JAK/STAT) ho khothaletsa karohano ea lisele le ho thibela apoptosis ea lisele, ho etsa hore lisele li ate hampe, ka hona li baka ho hlaha ha CML.
BCR-ABL fusion gene, e bohlokoa ho nts'etsopele ea CML, e sebetsa e le letšoao la bohlokoa la tlhahlobo. ea CML. Ho fumanoa ha eona ho thusa ho beha mokuli leihlo's karabo ho tyrosine kinase inhibitors (TKIs) le ho bolela esale pele ho khutla ha kankere ea mali, e leng ea bohlokoa ho laola bakuli ba CML ka katleho.
Motho BCR-ABLFusion Gene Mutation Setection Kitho tsoa ho Macro & Micro-Test bakeng sa tlhahlobo ea boleng ba BCR-ABL ho bakuli ba CML, e thusa ho hlahloba CML le ho tataisa liphekolo tse lebisitsoeng tsa bongaka ho ntlafatsa mekhoa ea phekolo bakeng sa tsamaiso e sebetsang ea bakuli.BCR-ABL fusion gene, seokebohlokoantshetsopeleng ya CML,e sebetsa joalo ka lesupa la bohlokoa la tlhahloboofCML. Ho fumanoa ha eona ho thusa hohlokomelamokuli'skarabo ho tyrosine kinase inhibitors (TKIs)lee bolela esale pele ho hlaha ha leukemia, e lengbohlokoato e sebetsang hantleCMLtaolo ya mokuli.
Batho BCR-ABL Fusion Gene Mutation Detection Kit ho tsoa ho Macro & Micro-Test bakeng sa tlhahlobo ea boleng ba BCR-ABL ho bakuli ba CML, thusaCMLtlhahlobolebatataisiliphekolo tsa kliniki tse lebisitsoengtooptimizeemekhoa ea phekolo ea ho laola mokuli ka katleho.
Ka botlaloDtlhahiso:Ka nako e le nngweho lemohabakeng sa3mefuta e tloaelehileng ea motsoako (P210, P190, P230)bakeng sakabo e pharaletseng lethibelo ea linyeoe tse hlolohetsoeng;
Kutloelo-bohloko e Phahameng:Mofuta oa mokelikeli o lemoha liphatsa tsa lefutso tse kopanengle LoDlikopi tse 1000 / ml,le mofuta oa lyophilizedof 500 likopi / mL;
E kgabaneAho nepahala: Itsa nahataolole enzyme ea UNG ho thibela lintho tse fosahetseng&tse mpe;
Tšebetso e Bonolo le Bokhabane:Ts'ebetso ea tube e koetsoeng,ntle le lihlahisoaka mor'a ts'ebetso,leho lemohaka hareMetsotso e 60bakeng sasepheo le liphetho tse tšepahalang;
HapeDikgetho:Liphetolelo tsa metsi le lyophilized bakeng sa likhetho tsa bareki;
Bophara ba Tšebelisano:E lumellana le litsamaiso tse ngata tsa PCR bakeng sa phihlello ea lab e pharaletseng.
Ka botlaloDtlhahiso:Ka nako e le nngweho lemohabakeng sa3mefuta e tloaelehileng ea motsoako (P210, P190, P230)bakeng sakabo e pharaletseng lethibelo ea linyeoe tse hlolohetsoeng;
Kutloelo-bohloko e Phahameng:Mofuta oa mokelikeli o lemoha liphatsa tsa lefutso tse kopanengle LoDlikopi tse 1000 / ml,le mofuta oa lyophilizedof 500 likopi / mL;
E kgabaneAho nepahala: Itsa nahataolole enzyme ea UNG ho thibela lintho tse fosahetseng&tse mpe;
Tšebetso e Bonolo le Bokhabane:Ts'ebetso ea tube e koetsoeng,ntle le lihlahisoaka mor'a ts'ebetso,leho lemohaka hareMetsotso e 60bakeng sasepheo le liphetho tse tšepahalang;
HapeDikgetho:Liphetolelo tsa metsi le lyophilized bakeng sa likhetho tsa bareki;
Bophara ba Tšebelisano:E lumellana le litsamaiso tse ngata tsa PCR bakeng sa phihlello ea lab e pharaletseng.
Nako ea poso: May-16-2024