Selemo se seng le se seng ka la 17 Mmesa ke Letsatsi la Lefatše la Kankere.
Kakaretso ea 01 ea Ketsahalo ea Kankere Lefatšeng
Lilemong tsa morao tjena, ka keketseho e tsoelang pele ea bophelo ba batho le khatello ea kelello, palo ea lihlahala le eona e ntse e eketseha selemo le selemo.
Lihlahala tse kotsi (kankere) e se e le e 'ngoe ea mathata a maholo a bophelo bo botle ba sechaba a sokelang bophelo bo botle ba baahi ba Chaena ka ho teba. Ho ea ka lintlha tsa morao-rao tsa lipalo-palo, lefu la lihlahala tse kotsi le baka 23.91% ea lisosa tsohle tsa lefu har'a baahi, 'me palo ea lihlahala tse kotsi le lefu li ntse li eketseha lilemong tse leshome tse fetileng. Empa kankere ha e bolele "kahlolo ea lefu." Mokhatlo oa Lefatše oa Bophelo o boletse ka ho hlaka hore hafeela e fumanoa kapele, 60%-90% ea kankere e ka phekoloa! Karolo ea boraro ea kankere e ka thibeloa, karolo ea boraro ea kankere e ka phekoloa, 'me karolo ea boraro ea kankere e ka phekoloa ho lelefatsa bophelo.
02 Hlahala ke eng
Hlahala e bolela ntho e ncha e entsoeng ke ho ata ha lisele tsa lisele tsa lehae tlas'a ts'ebetso ea mabaka a fapaneng a hlahala. Lithuto li fumane hore lisele tsa hlahala li feta liphetohong tsa metabolism tse fapaneng le lisele tse tloaelehileng. Ka nako e ts'oanang, lisele tsa hlahala li ka ikamahanya le liphetoho tikolohong ea metabolism ka ho fetola pakeng tsa glycolysis le phosphorylation ea oxidative.
03 Kalafo ea Kankere e Ikhethileng
Kalafo ea kankere e ikhethileng e ipapisitse le tlhahisoleseling ea tlhahlobo ea liphatsa tsa lefutso tse reretsoeng lefu le liphetho tsa lipatlisiso tsa bongaka tse thehiloeng bopaking. E fana ka motheo oa hore bakuli ba fumane moralo o nepahetseng oa kalafo, e leng mokhoa oa nts'etsopele ea bongaka ea sejoale-joale. Lithuto tsa bongaka li tiisitse hore ka ho lemoha phetoho ea liphatsa tsa lefutso tsa li-biomarker, mofuta oa SNP ea liphatsa tsa lefutso, liphatsa tsa lefutso le boemo ba tlhahiso ea protheine ea tsona lisampoleng tsa baeloji tsa bakuli ba hlahala ho bolela esale pele katleho ea lithethefatsi le ho lekola tebello ea lefu, le ho tataisa kalafo ea bongaka e ikhethileng, e ka ntlafatsa katleho le ho fokotsa likarabelo tse mpe, ho khothaletsa tšebeliso e utloahalang ea lisebelisoa tsa bongaka.
Liteko tsa limolek'hule bakeng sa kankere li ka aroloa ka mefuta e meraro e meholo: tlhahlobo, lefutso, le phekolo. Liteko tsa phekolo ke motheo oa seo ho thoeng ke "phekolo ea kalafo" kapa meriana e etselitsoeng motho ka mong, 'me li-antibodies tse ngata le li-inhibitor tse nyane tsa limolek'hule tse ka shebanang le liphatsa tsa lefutso tsa bohlokoa tse ikhethileng le litsela tsa lipontšo li ka sebelisoa kalafong ea lihlahala.
Kalafo e shebaneng le limolek'hule ea lihlahala e shebana le limolek'hule tse tšoaeang tsa lisele tsa hlahala 'me e kenella ts'ebetsong ea lisele tsa mofetše. Tšusumetso ea eona e ho lisele tsa hlahala haholo-holo, empa ha e na tšusumetso e kholo ho lisele tse tloaelehileng. Li-receptor tsa kholo ea hlahala, limolek'hule tsa phetisetso ea matšoao, liprotheine tsa potoloho ea sele, balaoli ba apoptosis, lienzyme tsa proteolytic, vascular endothelial growth factor, jj. kaofela li ka sebelisoa e le lipheo tsa limolek'hule bakeng sa kalafo ea hlahala. Ka la 28 Tšitoe 2020, "Mehato ea Tsamaiso bakeng sa Ts'ebeliso ea Bongaka ea Meriana ea Antineoplastic (Teko)" e fanoeng ke Khomishene ea Naha ea Bophelo bo Botle le Bongaka e bontšitse ka ho hlaka hore: Bakeng sa meriana e nang le lipheo tse hlakileng tsa liphatsa tsa lefutso, molao-motheo oa ho li sebelisa o tlameha ho lateloa kamora tlhahlobo ea liphatsa tsa lefutso tse tobileng.
04 Teko ea liphatsa tsa lefutso e shebaneng le hlahala
Ho na le mefuta e mengata ea liphetoho tsa lefutso lihlahleng, 'me mefuta e fapaneng ea liphetoho tsa lefutso e sebelisa meriana e fapaneng e reretsoeng. Bakuli ba ka rua molemo feela ka ho hlakisa mofuta oa phetoho ea liphatsa tsa lefutso le ho khetha kalafo e reretsoeng ka nepo. Mekhoa ea ho lemoha limolek'hule e sebelisitsoe ho lemoha phapang ea liphatsa tsa lefutso tse amanang le meriana e reretsoeng lihlahleng. Ka ho sekaseka tšusumetso ea mefuta e fapaneng ea liphatsa tsa lefutso katlehong ea meriana, re ka thusa lingaka ho theha moralo oa kalafo o nepahetseng ka ho fetisisa oa motho ka mong.
Tharollo ea 05
Macro & Micro-Test e hlahisitse letoto la lisebelisoa tsa ho lemoha liphatsa tsa lefutso tsa hlahala, tse fanang ka tharollo e akaretsang bakeng sa phekolo e shebaneng le hlahala.
Kiti ea ho Fumana Liphetoho tsa EGFR Gene 29 ea Motho (Phatsimo ea PCR ea Fluorescence)
Sete ena e sebelisetsoa ho lemoha ka botlalo liphetoho tse tloaelehileng ho li-exons 18-21 tsa gene ea EGFR lisampoleng tse tsoang ho bakuli ba kankere ea matšoafo ba batho ba seng lisele tse nyane.
1. Sistimi e hlahisa taolo ea boleng ba litšupiso tsa ka hare, e ka behang leihlo ka botlalo ts'ebetso ea liteko le ho netefatsa boleng ba teko.
2. Kutloisiso e phahameng: Ho lemoha tharollo ea karabelo ea nucleic acid ho ka lemoha ka mokhoa o tsitsitseng sekhahla sa phetoho ea 1% tlas'a semelo sa mofuta oa naha oa 3ng/μL.
3. Ho hlaka ho hoholo: Ha ho karabelo e kopaneng le DNA ea genomic ea motho ea mofuta oa hlaha le mefuta e meng ea liphetoho.
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KRAS 8 Transtations Detection Kit (Fluorescence PCR)
Sete ena e etselitsoe ho lemoha liphetoho tse 8 ka har'a li-codon 12 le 13 tsa gene ea K-ras ka har'a DNA e ntšitsoeng likarolong tsa pathological tse kentsoeng ka parafini ho batho.
1. Sistimi e hlahisa taolo ea boleng ba litšupiso tsa ka hare, e ka behang leihlo ka botlalo ts'ebetso ea liteko le ho netefatsa boleng ba teko.
2. Kutloisiso e phahameng: Ho lemoha tharollo ea karabelo ea nucleic acid ho ka lemoha ka mokhoa o tsitsitseng sekhahla sa phetoho ea 1% tlas'a semelo sa mofuta oa naha oa 3ng/μL.
3. Ho hlaka ho hoholo: Ha ho karabelo e kopaneng le DNA ea genomic ea motho ea mofuta oa hlaha le mefuta e meng ea liphetoho.
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Kiti ea ho Fumana Phetoho ea Liphatsa tsa Lefutso ea EML4-ALK ea Motho (Fluorescence PCR)
Sete ena e sebelisetsoa ho lemoha ka boleng mefuta e 12 ea phetoho ea liphatsa tsa lefutso tsa EML4-ALK fusion lisampoleng tsa bakuli ba kankere ea matšoafo ea lisele tse nyenyane tsa batho ka ntle ho laboratori.
1. Sistimi e hlahisa taolo ea boleng ba litšupiso tsa ka hare, e ka behang leihlo ka botlalo ts'ebetso ea liteko le ho netefatsa boleng ba teko.
2. Kutloisiso e phahameng: Kiti ena e ka lemoha liphetoho tsa motsoako tse fihlang ho likopi tse 20.
3. Ho hlaka ho hoholo: Ha ho karabelo e kopaneng le DNA ea genomic ea motho ea mofuta oa hlaha le mefuta e meng ea liphetoho.
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Kiti ea ho Fumana Phetoho ea Liphatsa tsa Lefutso ea ROS1 ea Motho (Fluorescence PCR)
Sete ena e sebelisetsoa ho lemoha mefuta e 14 ea liphetoho tsa liphatsa tsa lefutso tsa ROS1 lisampoleng tsa kankere ea matšoafo tsa batho tse seng lisele tse nyane.
1. Sistimi e hlahisa taolo ea boleng ba litšupiso tsa ka hare, e ka behang leihlo ka botlalo ts'ebetso ea liteko le ho netefatsa boleng ba teko.
2. Kutloisiso e phahameng: Kiti ena e ka lemoha liphetoho tsa motsoako tse fihlang ho likopi tse 20.
3. Ho hlaka ho hoholo: Ha ho karabelo e kopaneng le DNA ea genomic ea motho ea mofuta oa hlaha le mefuta e meng ea liphetoho.
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Kiti ea ho Fumana Phetoho ea Gene V600E ea Motho (Fluorescence PCR)
Sete ena ea liteko e sebelisetsoa ho fumana phetoho ea liphatsa tsa lefutso tsa BRAF V600E ka boleng lisampoleng tsa lisele tse kentsoeng ka parafini tsa melanoma ea motho, kankere ea mala a maholo, kankere ea thyroid le kankere ea matšoafo ka ntle ho laboratori.
1. Sistimi e hlahisa taolo ea boleng ba litšupiso tsa ka hare, e ka behang leihlo ka botlalo ts'ebetso ea liteko le ho netefatsa boleng ba teko.
2. Kutloisiso e phahameng: Ho lemoha tharollo ea karabelo ea nucleic acid ho ka lemoha ka mokhoa o tsitsitseng sekhahla sa phetoho ea 1% tlas'a semelo sa mofuta oa naha oa 3ng/μL.
3. Ho hlaka ho hoholo: Ha ho karabelo e kopaneng le DNA ea genomic ea motho ea mofuta oa hlaha le mefuta e meng ea liphetoho.
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| Nomoro ea Khataloge | Lebitso la Sehlahisoa | Tlhaloso |
| HWTS-TM012A/B | Kiti ea ho Fumana Liphetoho tsa Gene 29 ea Motho ea EGFR (Fluorescence PCR） | Liteko tse 16/sete, liteko tse 32/sete |
| HWTS-TM014A/B | KRAS 8 Transtations Detection Kit (Fluorescence PCR) | Liteko tse 24/sete, liteko tse 48/sete |
| HWTS-TM006A/B | Kiti ea ho Fumana Phetoho ea Liphatsa tsa Lefutso ea EML4-ALK ea Motho (Fluorescence PCR) | Liteko tse 20/sete, liteko tse 50/sete |
| HWTS-TM009A/B | Kiti ea ho Fumana Phetoho ea Liphatsa tsa Lefutso ea ROS1 ea Motho (Fluorescence PCR) | Liteko tse 20/sete, liteko tse 50/sete |
| HWTS-TM007A/B | Kiti ea ho Fumana Phetoho ea Gene V600E ea Motho (Fluorescence PCR) | Liteko tse 24/sete, liteko tse 48/sete |
| HWTS-GE010A | Kiti ea ho Fumana Phetoho ea Liphatsa tsa Lefutso ea BCR-ABL ea Motho (Fluorescence PCR) | Liteko tse 24/kit |
Nako ea poso: Mmesa-17-2023