Ho tloha ka Mots'eanong 2022, linyeoe tsa mpox li tlalehiloe linaheng tse ngata tse sa pheleng lefats'eng ka phetisetso ea sechaba.
Ka la 26 Phato, Mokhatlo oa Lefatše oa Bophelo (WHO) o ile oa tsebisa lefatše lohleTokiso ea Leano le Moralo oa Karabeloho thibela ho qhoma ha tšoaetso ea mpox ho tloha ho motho ho ea ho motho ka boiteko bo hokahaneng ba lefats'e, ba libaka le ba naha. Sena se latela phatlalatso ya tshohanyetso ya bophelo bo botle ba setjhaba ya matshwenyeho a matjhaba ke Motsamaisikakaretso wa WHO ka la 14 Phato.
Ho ke ho hlokomeloe hore ho qhoma ha mpox khetlong lena ho fapane le ha 2022, e neng e hasana haholo har'a banna ba robalang le banna, 'me sekhahla sa ho shoa ha batho ba nang le tšoaetso se ne se le ka tlaase ho 1%.
Mofuta oa morao-rao o atileng oa "Clade Ib", e leng mofuta oa Clade I, o na le sekhahla se phahameng sa batho ba shoang. Phapang ena e ncha e qalile ho ata DRC selemong se fetileng ka Loetse, qalong e ne e le har'a barekisi ba thobalano, 'me joale e se e nametse lihlopheng tse ling, moo bana ba leng kotsing haholo.
Africa CDC e boletse tlalehong ea khoeli e fetileng hore ho fumanoe ho phatloha ha mpox linaheng tse 10 tsa Afrika selemong sena, ho kenyeletsoa DRC, e tlalehileng 96.3% ea linyeoe tsohle tsa Afrika selemong sena le 97% ea batho ba shoang. Ke habohlokoa ho hlokomela hore hoo e ka bang 70% ea linyeoe tsa DRC ke bana ba ka tlaase ho lilemo tse 15, 'me sehlopha sena se etsa 85% ea batho ba shoang naheng eo.
Mpox ke zoonosis e bakoang ke kokoana-hloko ea mpox e nang le nako ea matsatsi a 5 ho isa ho a 21, haholo-holo matsatsi a 6 ho isa ho a 13. Motho ea tšoaelitsoeng o tla ba le matšoao a kang feberu, hlooho e opang le ho ruruha li-lymph nodes, ho lateloe ke lekhopho sefahlehong le likarolong tse ling tsa 'mele, ebe butle-butle e fetoha pustules 'me e tšoarella nako e ka etsang beke pele a khopa. Nyeoe e tšoaetsanoa ho tloha qalong ea matšoao ho fihlela likhopo li oela ka tlhaho.
Macro & Micro-Test e fana ka liteko tse potlakileng, lisebelisoa tsa limolek'hule le litharollo tsa tatellano bakeng sa ho lemoha kokoana-hloko ea mpox, ho thusa ho hlahlojoa ha kokoana-hloko ea mpox ka nako, tlhokomelo ea tšimoloho ea eona, leloko, phetisetso le mefuta e fapaneng ea genomic:
Antigen ea kokoana-hloko ea MonkeypoxSetsi sa ho lemoha (Immunochromatography)
Sampling e bonolo (rash fluid / throat sample) le phello e potlakileng ka hare ho 10-15 min;
Kutloelo-bohloko e phahameng e nang le LoD ea 20pg/mL e koahelang Clade I & II;
Boemo bo phahameng bo se nang cross-reactivity le kokoana-hloko ea sekholopane, kokoana-hloko ea varicella zoster, kokoana-hloko ea rubella, kokoana-hloko ea herpes simplex, joalo-joalo.
OPA ea 96.4% ha e bapisoa le NAATs;
Sesebelisoa se pharaletseng joalo ka litloaelo, li-CDC, likhemisi, litleliniki, lipetlele kapa lapeng.
Monkeypox-virus IgM/IgG Antibody Detection Kit(Immunochromatographhy)
Ts'ebetso e bonolo ntle le lisebelisoa le sephetho se potlakileng nakong ea metsotso e 10;
Boikutlo bo phahameng le bo ikhethang bo koahelang Clade I & II;
E khetholla IgM le IgG ho etsa qeto ea mekhahlelo ea tšoaetso ea mpox;
Sesebelisoa se pharaletseng joalo ka litloaelo, li-CDC, li-pharmacy, litleliniki, lipetlele kapa lapeng;
E loketseng tlhahlobo e kholo ea tšoaetso ea mpox e belaelloang.
Monkeypox Virus Nucleic Acid Detection Kit (Enzymatic Probe Isothermal Amplification)
Kutloelo-bohloko e phahameng ka LoD ea Likopi tse 200 / mL e nang le IC, e lekanang le florescence PCR;
Ts'ebetso e bonolo: sampole ea Lysed e kenyellelitsoeng ho tube ea reagent e nang le lyophilized bakeng sa ho holisa ka kotloloho ho hlokehang ho nolofalitsoeng ke li-module tse ikemetseng tsa Easy Amp System;
Ho hlaka ho hoholo ntle le ho ts'oaroa hape le kokoana-hloko ea sekholopane, kokoana-hloko ea vaccinia, kokoana-hloko ea cowpox, kokoana-hloko ea mouse, kokoana-hloko ea herpes simplex, varicella-zoster virus, le genome ea motho, joalo-joalo;
Sampling e bonolo (rash fluid / oropharyngeal swab) le sephetho se potlakileng ka ho fetesisa nakong ea 5 min;
Ts'ebetso e ntle haholo ea kliniki e koahelang Clade I & II e nang le PPA ea 100%, NPA ea 100%, OPA ea 100% le Kappa Value ea 1.000 ha e bapisoa le Fluorescence PCR kit;
Mofuta oa Lyophilized o hlokang feela lipalangoang tsa mocheso oa kamore le polokelo o nolofalletsa ho fihlella libakeng tsohle;
Maemo a feto-fetohang litleliniking, setsing sa tlhokomelo ea bophelo, hammoho le Easy Amp bakeng sa ho fumanoa ha ho hlokahala;
Monkeypox Virus Nucleic Acid Detection Kit (Fluorescence PCR)
Liphatsa tsa lefutso tse peli tse lebisitsoeng ka kutloisiso e phahameng ka LoD ea likopi tse 200 / mL;
sampuli e feto-fetohang ea lekhopho mokelikeli, 'metso swab le serum;
Ho hlaka ho hoholo ntle le ho ts'oaroa hape le kokoana-hloko ea sekholopane, kokoana-hloko ea vaccinia, kokoana-hloko ea cowpox, kokoana-hloko ea mouse, kokoana-hloko ea herpes simplex, varicella-zoster virus, le genome ea motho, joalo-joalo;
Ts'ebetso e bonolo: sampole e potlakileng ea lysis ka sampole ea tokollo e lokelang ho eketsoa ho tube ea karabelo;
Ho lemoha ka potlako: sephetho ka hare ho 40 min;
Ho nepahala ho netefalitsoeng ke taolo ea kahare e okametseng ts'ebetso eohle ea ho lemoha;
Ts'ebetso e ntle ea bongaka e akaretsang Clade I & II e nang le PPA ea 100%, NPA ea 99.40%, OPA ea 99.64% le Kappa Value ea 0.9923 ha e bapisoa le tatellano;
Mofuta oa Lyophilized o hlokang feela lipalangoang tsa mocheso oa kamore le polokelo o nolofalletsa ho fihlella libakeng tsohle;
E lumellana le mekhoa e tloaelehileng ea Fluorescence PCR Systems;
Maemo a feto-fetohang bakeng sa lipetlele, li-CDC le li-labs;
Orthopox Virus Universal Type/Monkeypox Virus Nucleic Acid Detection Kit (Fluorescence PCR)
Kakaretso e feletseng: e lekola likokoana-hloko tsohle tsa 4 tsa orthopox tse ka tšoaetsang motho le mpox e atileng (Clade I & II e kenyelelitsoe) tekong e le 'ngoe ho qoba ho fumanoa ho fosahetseng;
Kutloelo-bohloko e phahameng ka LoD ea likopi tse 200 / mL;
E phahameng ka ho khetheha ntle le ho ts'oaroa ha sefapano le likokoana-hloko tse ling tse bakang makhopho a kang kokoana-hloko ea herpes simplex, kokoana-hloko ea varicella-zoster, le genome ea motho, joalo-joalo;
Ts'ebetso e bonolo: sampole e potlakileng ea lysis ka sampole ea tokollo e tla kenyelletsoa ho buffer e le 'ngoe ea karabelo ea tube;
Ho lemoha ka potlako: ho holisa ka potlako ka sephetho ka hare ho 40 min;
Ho nepahala ho netefalitsoeng ke taolo ea kahare e okametseng ts'ebetso eohle ea ho lemoha;
E lumellana le mekhoa e tloaelehileng ea Fluorescence PCR Systems;
Maemo a feto-fetohang bakeng sa lipetlele, li-CDC le li-labs;
TshweneVirus TypingNucleicAcidDetectionKeona (Fluorescence PCR)
Ka nako e le 'ngoe e supa Clade I le Clade II, e leng bohlokoa bakeng sa ho utloisisa litšobotsi tsa lefu la kokoana-hloko, ho latela phetiso ea eona, le ho etsa mehato e reretsoeng ea thibelo le taolo.
Kutloelo-bohloko e phahameng ka LoD ea likopi tse 200 / mL;
sampuli e feto-fetohang ea rash fluid, oropharyngeal swab le serum;
E phahameng ka ho khetheha ntle le cross reactivity pakeng tsa Clade I le II, likokoana-hloko tse ling tse bakang makhopho a kang kokoana-hloko ea herpes simplex, varicella-zoster virus, le genome ea motho, joalo-joalo;
Ts'ebetso e bonolo: sampole e potlakileng ea lysis ka sampole ea tokollo e tla kenyelletsoa ho buffer e le 'ngoe ea karabelo ea tube;
Ho lemoha ka potlako: sephetho ka hare ho 40 min;
Ho nepahala ho netefalitsoeng ke taolo ea kahare e okametseng ts'ebetso eohle ea ho lemoha;
Mofuta oa Lyophilized o hlokang feela lipalangoang tsa mocheso oa kamore le polokelo o nolofalletsa ho fihlella libakeng tsohle;
E lumellana le mekhoa e tloaelehileng ea Fluorescence PCR Systems;
Maemo a feto-fetohang bakeng sa lipetlele, li-CDC le li-labs;
Monkey Virus Universal Whole GenomeHo lemohaKit (Multi-PCR NGS)
Monkeypox Virus Whole Genome Detection Kit e sa tsoa ntlafatsoa ke Macro & Micro-Test bakeng sa maemo a fapaneng, e kopantsoeng le sequencer ea ONT nanopore, e ka fumana tatellano ea liphatsa tsa lefutso tsa MPXV ka tšireletso e seng ka tlase ho 98% nakong ea lihora tse 8.
Ho bonolo ho sebetsa: thekenoloji e nang le tokelo ea ho hōlisa mohato o le mong, tatellano eohle ea genome ea kokoana-hloko ea mpox e ka fumanoa ka amplification e le 'ngoe;
E utloahala ebile e nepahetse: e lemoha mehlala e tlase ho 32CT, 'me 600bp amplicon nanopore sequencing e ka kopana le kopano ea boleng bo phahameng ba genome;
Ka potlako haholo: ONT e ka phethela kopano ea genome nakong ea lihora tse 6-8;
Khokahano e pharalletseng: le ONT, Qi Carbon, SALUS Pro, lllumina, MGI le tse ling tse 2 tsa mantlha.ndle 3rdmeloko e latellanang.
Haholo-hlokoMonkey Virus Whole GenomeHo lemohaKit-Illumina/MGI(Multi-PCR NGS)
Mabapi le palo e kholo ea tse teng 2ndli-sequencers tsa moloko lefatšeng ka bophara, Macro & Micro-Test e boetse e thehile lisebelisoa tsa morao-rao tse ikamahanyang le li-sequencers tse tloaelehileng ho finyella tatellano e tlaase ea kokoana-hloko ea kokoana-hloko ea genome;
Amplification e sebetsang hantle: lipara tsa 1448 tsa 200bp amplicon ultra-dense primer design bakeng sa katleho e phahameng ea amplification le tšireletso e tšoanang;
Ts'ebetso e bonolo: Laeborari ea Mpox virus llumina / MGI e ka fumanoa ka ho holisoa ka makhetlo a mabeli ka lihora tsa 4, ho qoba mehato e rarahaneng ea kaho ea laebrari le litšenyehelo tsa reagent;
Kutloelo-bohloko e phahameng: e lemoha lisampole tse tlase ho 35CT, ka katleho e qoba liphetho tse fosahetseng tse bakoang ke ho senyeha ha likhechana kapa palo e tlase ea kopi;
Khokahano e pharalletseng le tse tloaelehileng 2ndli-sequencers tsa moloko tse kang lllumina, Salus Pro kapa MGI;Ho tla fihlela joale, linyeoe tse fetang 400 tsa bongaka li se li phethiloe.
Nako ea poso: Aug-28-2024